Structural Biology & Cryo-EM

Structural biology tools for analyzing three-dimensional structures of proteins, nucleic acids, and molecular complexes. Process cryo-EM data, predict structures, and refine atomic models.

Overview

This collection includes workflows for:

• Cryo-EM Processing - Single particle analysis and reconstruction
• Structure Prediction - AI-powered protein structure modeling
• Structure Refinement - Model building and validation
• Visualization - Interactive molecular graphics
• Data Analysis - Resolution estimation and quality assessment

Available Workflows

Browse the workflows in this category to find structural biology tools. Each workflow includes processing pipelines, parameter guides, and validation methods.

System Requirements

Workstation:

• CPU: 16+ cores
• RAM: 64GB minimum
• GPU: NVIDIA RTX 3090 or better
• Storage: 2TB+ NVMe SSD

HPC Cluster (for large datasets):

• Multiple GPU compute nodes
• 256GB+ RAM per node
• High-speed parallel filesystem
• GPU-optimized interconnect

Getting Started

Deploy structural biology workflows:

# Deploy a cryo-EM or structure workflow
dxflow compose create --identity <workflow-name> <compose-file>
dxflow compose start <workflow-name>

Explore the workflows below to determine high-resolution structures!